关键词：apoptosis autophagy inhibitors epilepsy rapamycin 

摘要：Objective:Xenon is an inhalation anesthetic with a favorable safety profile,and previous studies have demonstrated the neuroprotective efficacy of xenon in Alzheimer’s disease,spinal cord ischemia/reperfusion injury,intrauterine asphyxia and neonatal asphyxia.Further studies confirmed the inhibition of uptake and efflux of glutamate and mediating the neuroprotective effect through the inhibition of excessive excitation and anti-apoptosis.However,whether xenon plays a role in epilepsy remains unclear.This study aimed to investigate the role of xenon treatment in kainic acid(KA)-induced acute generalized epileptic seizures in male Sprague-Dawley rats.Methods:All rats were treated with KA(1 mg/0.8 ml,0.65μl/rat),which was injected into the lateral ventricle through the cannula.Seizure severity was staged as 1~5 based on Racine’s criteria.Rats in the xenon group were treated with xenon mixture(70%xenon/30%oxygen)for 1 h immediately after KA injection,while rats in the control group were treated with 70%nitrogen/30%oxygen.In order to assess the role of autophagy in the antiepileptic effects induced by xenon,the inhibitors of autophagy(3-methyladenine,3-MA or bafilomycin A1,BafA1)and the inducer of autophagy(rapamycin)were administered before xenon inhalation

神经药理学报杂志要求:

{1}包括真实姓名、性别、出生年、职务职称、学位、研究方向、联系电话、E-mail、邮编等。

{2}文稿应论点明确、资料可靠、数据精确、文字精炼、层次清晰。

{3}年份中的前两位数不可省略，如：‘'01年”应为“2001年”。

{4}注释：主要用于对文章篇名、作者及文内某一专题内容作必要的解释或说明。序号在注释处右上角用阿拉伯数字①②等表示。

{5}正文应尽量减少层次，一般不宜超过3层。有标题内容才列数字序号（没有标题的内容用自然段形式起始），数字序号后不用加点，但要空1格。

注：因版权方要求，不能公开全文，如需全文，请咨询杂志社