S1-1 Xenon Exerts Antiepileptic Effects via Increased Autophagy on Kainic Acid-Induced Acute Generalized Seizures in Rats

关键词: apoptosis  autophagy  inhibitors  epilepsy  rapamycin  xenon  inhalation  

Objective:Xenon is an inhalation anesthetic with a favorable safety profile,and previous studies have demonstrated the neuroprotective efficacy of xenon in Alzheimer’s disease,spinal cord ischemia/reperfusion injury,intrauterine asphyxia and neonatal asphyxia.Further studies confirmed the inhibition of uptake and ef...

S1-2 The 5-HT6 Receptor-Related Mechanism for the Cognition-Enhancing Properties of Hypidone Hydrochloride(YL-0919),A Novel Protential Antidepressant

关键词: hypidone  receptor  agonist  cognitionenhancing  antidepressant  anxiolytic  camp  

Hypidone hydrochloride(YL-0919),the 5-HT1A/6 agonists and 5-HT reuptake inhibitor,is a novel potent antidepressant with original chemical structure.Previous studies confirmed that YL-0919 has significant antidepressant-and anxiolytic-like effects.Compared with first-line antidepressants,YL-0919 possesses rapid-onset ...

S1-3 Effects and Mechanisms of Depression on Bone Fracture Healing in Rats

关键词: depression  fracture  healing  alkaline  phosphatase  rats  

S1-4 Chronic Nicot ine Treatment Alleviates Schizophrenia-Induced Memory Deficit through Regulating Pdlim5 and CRTC1 in Mice

关键词: schizophrenia  cognitive  impairment  nicotine  pdlim5  crtc1  

Objective:Cognitive impairment is a core deficit of schizophrenia and current antipsychotic treatments have no or only very limited effects on cognitive impairment.Clinical studies have found that about 50%~90%of all psychiatric patients are smokers,and the high rate of smoking may be due to the fact that the patient...

S1-5 Effects of Osthole on Learning and Memory and the Estrogen Pathway in Ovariectomized Rats

关键词: osthole  estradiol  disease  ovariectomized  learning  and  memory  

S1-6 PDE4 Inhibitor Ameliorates Neuropathic Pain by Upregulating Spinal Connexin 43 Expression

关键词: connexin43  rolipram  roflumilast  neuropathic  pain  

Peripheral nerve injury downregulates connexin43(Cx43)expression in spinal astrocytes.Therefore,restoration of spinal astrocyte Cx43 expression to normal levels could lead to the reduction of nerve injury-induced pain.It has been shown that inhibitors of phosphodiesterase-4(PDE4),an enzyme catalyzing the hydrolysis o...

S1-7 Inhibition of Phosphodiesterase-2 Activity in the Amygdala Produces Anxiolytic-Like Effects in Mice

关键词: anxiety  bay  amygdala  microrna  mice  

Objective To explore the role of phosphodiesterase-2 activity in the amygdala produces anxiolytic-like effects in mice.Methods:Male ICR mice were implanted with guide cannula targeting the central nucleus of the amygdala bilaterally.Following recovery from surgery,mice were administered either Bay 60-7550 or lentivir...